IL-7 signalling represses Bcl-6 and the T(FH) gene program

The transcriptional repressor Bcl-6 is linked to the development of both CD4(+) T follicular helper (T(FH)) and central memory T (T(CM)) cells. Here, we demonstrate that in response to decreased IL-2 signalling, T helper 1 (T(H)1) cells upregulate Bcl-6 and co-initiate T(FH)- and T(CM)-like gene pro...

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Bibliographic Details
Published in:Nat Commun
Main Authors: McDonald, Paul W., Read, Kaitlin A., Baker, Chandra E., Anderson, Ashlyn E., Powell, Michael D., Ballesteros-Tato, André, Oestreich, Kenneth J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729877/
https://ncbi.nlm.nih.gov/pubmed/26743592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10285
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