Ezh2 programs T(FH) differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

Ezh2 is an histone methyltransferase (HMT) that catalyzes H3K27me3 and functions in T(H)1, T(H)2, and Treg cells primarily via HMT activity. Here we show that Ezh2 ablation impairs T follicular helper (T(FH)) cell differentiation and activation of the T(FH) transcription program. In T(FH) cells, mos...

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Publicat a:Nat Commun
Autors principals: Li, Fengyin, Zeng, Zhouhao, Xing, Shaojun, Gullicksrud, Jodi A., Shan, Qiang, Choi, Jinyong, Badovinac, Vladimir P., Crotty, Shane, Peng, Weiqun, Xue, Hai-Hui
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303346/
https://ncbi.nlm.nih.gov/pubmed/30575739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07853-z
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