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LEF-1 and TCF-1 orchestrate T follicular helper cell differentiation by regulating differentiation circuits upstream of Bcl6
T follicular helper (T(FH)) cells are specialized effector CD4(+) T cells that help B cells develop germinal centers and memory. However, the transcription factors that regulate T(FH) differentiation remain incompletely understood. Here we report that selective loss of either Lef1 (LEF-1) or Tcf7 (T...
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| Publicado no: | Nat Immunol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4545301/ https://ncbi.nlm.nih.gov/pubmed/26214741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3226 |
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