LEF-1 and TCF-1 orchestrate T follicular helper cell differentiation by regulating differentiation circuits upstream of Bcl6

T follicular helper (T(FH)) cells are specialized effector CD4(+) T cells that help B cells develop germinal centers and memory. However, the transcription factors that regulate T(FH) differentiation remain incompletely understood. Here we report that selective loss of either Lef1 (LEF-1) or Tcf7 (T...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Immunol
Prif Awduron: Choi, Youn Soo, Gullicksrud, Jodi A., Xing, Shaojun, Zeng, Zhouhao, Shan, Qiang, Li, Fengyin, Love, Paul E., Peng, Weiqun, Xue, Hai-Hui, Crotty, Shane
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545301/
https://ncbi.nlm.nih.gov/pubmed/26214741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3226
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