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Runx3 guards cytotoxic CD8(+) effector T cells against deviation towards T(FH) cell lineage
Activated CD8(+) T cells differentiate into cytotoxic effector (T(EFF)) cells that eliminate target cells. How T(EFF) cell identity is established and maintained remains less understood. Here we show Runx3 deficiency limits clonal expansion and impairs upregulation of cytotoxic molecules in T(EFF) c...
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| Publicado en: | Nat Immunol |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5564218/ https://ncbi.nlm.nih.gov/pubmed/28604718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3773 |
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