Runx3 guards cytotoxic CD8(+) effector T cells against deviation towards T(FH) cell lineage

Activated CD8(+) T cells differentiate into cytotoxic effector (T(EFF)) cells that eliminate target cells. How T(EFF) cell identity is established and maintained remains less understood. Here we show Runx3 deficiency limits clonal expansion and impairs upregulation of cytotoxic molecules in T(EFF) c...

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Bibliografiset tiedot
Julkaisussa:Nat Immunol
Päätekijät: Shan, Qiang, Zeng, Zhouhao, Xing, Shaojun, Li, Fengyin, Hartwig, Stacey M., Gullicksrud, Jodi A., Kurup, Samarchith P., Van Braeckel-Budimir, Natalija, Su, Yao, Martin, Matthew D., Varga, Steven M., Taniuchi, Ichiro, Harty, John T., Peng, Weiqun, Badovinac, Vladimir P., Xue, Hai-Hui
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564218/
https://ncbi.nlm.nih.gov/pubmed/28604718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3773
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