Runx3 guards cytotoxic CD8(+) effector T cells against deviation towards T(FH) cell lineage

Activated CD8(+) T cells differentiate into cytotoxic effector (T(EFF)) cells that eliminate target cells. How T(EFF) cell identity is established and maintained remains less understood. Here we show Runx3 deficiency limits clonal expansion and impairs upregulation of cytotoxic molecules in T(EFF) c...

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Publicado no:Nat Immunol
Main Authors: Shan, Qiang, Zeng, Zhouhao, Xing, Shaojun, Li, Fengyin, Hartwig, Stacey M., Gullicksrud, Jodi A., Kurup, Samarchith P., Van Braeckel-Budimir, Natalija, Su, Yao, Martin, Matthew D., Varga, Steven M., Taniuchi, Ichiro, Harty, John T., Peng, Weiqun, Badovinac, Vladimir P., Xue, Hai-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564218/
https://ncbi.nlm.nih.gov/pubmed/28604718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3773
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