Runx3 guards cytotoxic CD8(+) effector T cells against deviation towards T(FH) cell lineage

Activated CD8(+) T cells differentiate into cytotoxic effector (T(EFF)) cells that eliminate target cells. How T(EFF) cell identity is established and maintained remains less understood. Here we show Runx3 deficiency limits clonal expansion and impairs upregulation of cytotoxic molecules in T(EFF) c...

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Библиографические подробности
Опубликовано в: :Nat Immunol
Главные авторы: Shan, Qiang, Zeng, Zhouhao, Xing, Shaojun, Li, Fengyin, Hartwig, Stacey M., Gullicksrud, Jodi A., Kurup, Samarchith P., Van Braeckel-Budimir, Natalija, Su, Yao, Martin, Matthew D., Varga, Steven M., Taniuchi, Ichiro, Harty, John T., Peng, Weiqun, Badovinac, Vladimir P., Xue, Hai-Hui
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564218/
https://ncbi.nlm.nih.gov/pubmed/28604718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3773
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