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Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8(+) T Cells and Heterosubtypic Immunity

Lung-resident primary memory CD8(+) T cell populations (T(rm)) induced by a single influenza infection decline within months, rendering the host susceptible to new heterosubtypic influenza infections. Here, we demonstrate that, relative to single virus exposure, repeated antigen exposure dramaticall...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Natalija Van, Braeckel-Budimir, Varga, Steven M., Badovinac, Vladimir P., Harty, John T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258017/
https://ncbi.nlm.nih.gov/pubmed/30257199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.073
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