Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine biosynthesis. Paradoxically, PHGDH and serine synthesis are required in the presence of abundant environmental serine even when serine uptake exceeds the requirements for nucleotide synthesis. Here, we establish a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Reid, Michael A., Allen, Annamarie E., Liu, Shiyu, Liberti, Maria V., Liu, Pei, Liu, Xiaojing, Dai, Ziwei, Gao, Xia, Wang, Qian, Liu, Ying, Lai, Luhua, Locasale, Jason W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303315/
https://ncbi.nlm.nih.gov/pubmed/30575741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07868-6
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