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Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism
Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine biosynthesis. Paradoxically, PHGDH and serine synthesis are required in the presence of abundant environmental serine even when serine uptake exceeds the requirements for nucleotide synthesis. Here, we establish a...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6303315/ https://ncbi.nlm.nih.gov/pubmed/30575741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07868-6 |
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