The NAD(+) Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis

NAD(+) is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD(+) salvage pathway. Here, we find that inhibiting the NAD(+) salvage pathway depletes serine biosynthesis from glucose by impeding the NAD(+)-dependent protein, 3-phosphoglycerate dehydrogenase (PHGDH). Im...

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Udgivet i:Cell Rep
Main Authors: Murphy, J. Patrick, Giacomantonio, Michael A., Paulo, Joao A., Everley, Robert A., Kennedy, Barry E., Pathak, Gopal P., Clements, Derek R., Kim, Youra, Dai, Cathleen, Sharif, Tanveer, Gygi, Steven P., Gujar, Shashi
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402325/
https://ncbi.nlm.nih.gov/pubmed/30157431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.086
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