The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle

The mitochondrial Ca(2+) uniporter (MCU) complex mediates acute mitochondrial Ca(2+) influx. In skeletal muscle, MCU links Ca(2+) signaling to energy production by directly enhancing the activity of key metabolic enzymes in the mitochondria. Here, we examined the role of MCU in skeletal muscle devel...

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Vydáno v:JCI Insight
Hlavní autoři: Kwong, Jennifer Q., Huo, Jiuzhou, Bround, Michael J., Boyer, Justin G., Schwanekamp, Jennifer A., Ghazal, Nasab, Maxwell, Joshua T., Jang, Young C., Khuchua, Zaza, Shi, Kevin, Bers, Donald M., Davis, Jennifer, Molkentin, Jeffery D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302934/
https://ncbi.nlm.nih.gov/pubmed/30429366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121689
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