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The mitochondrial calcium uniporter selectively matches metabolic output to acute contractile stress in the heart
In the heart, augmented Ca(2+) fluxing drives contractility and ATP generation through mitochondrial Ca(2+) loading. Pathologic mitochondrial Ca(2+) overload with ischemic injury triggers mitochondrial permeability transition pore (MPTP) opening and cardiomyocyte death. Mitochondrial Ca(2+) uptake i...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4497842/ https://ncbi.nlm.nih.gov/pubmed/26119742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.002 |
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