The mitochondrial calcium uniporter selectively matches metabolic output to acute contractile stress in the heart

In the heart, augmented Ca(2+) fluxing drives contractility and ATP generation through mitochondrial Ca(2+) loading. Pathologic mitochondrial Ca(2+) overload with ischemic injury triggers mitochondrial permeability transition pore (MPTP) opening and cardiomyocyte death. Mitochondrial Ca(2+) uptake i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Kwong, Jennifer Q., Lu, Xiyuan, Correll, Robert N., Schwanekamp, Jennifer A., Vagnozzi, Ronald J., Sargent, Michelle A., York, Allen J., Zhang, Jianyi, Bers, Donald M., Molkentin, Jeffery D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497842/
https://ncbi.nlm.nih.gov/pubmed/26119742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.002
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