Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference

Skeletal muscle mitochondria readily accumulate Ca(2+) in response to SR store-releasing stimuli thanks to the activity of the mitochondrial calcium uniporter (MCU), the highly selective channel responsible for mitochondrial Ca(2+) uptake. MCU positively regulates myofiber size in physiological cond...

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Vydáno v:Cell Death Differ
Hlavní autoři: Gherardi, Gaia, Nogara, Leonardo, Ciciliot, Stefano, Fadini, Gian Paolo, Blaauw, Bert, Braghetta, Paola, Bonaldo, Paolo, De Stefani, Diego, Rizzuto, Rosario, Mammucari, Cristina
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329801/
https://ncbi.nlm.nih.gov/pubmed/30232375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0191-7
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