Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

Icaritin is a natural flavonoid with anti-osteoporosis activity. This study aimed to characterize icaritin glucuronidation by pooled human liver microsomes (HLM) and pooled human intestine microsomes (HIM), and to determine the contribution of individual UDP-glucuronosyltrans-ferase (UGT) enzyme to...

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Detalhes bibliográficos
Publicado no:Xenobiotica
Main Authors: Wang, Li, Hong, Xiaodan, Yao, Zhihong, Dai, Yi, Zhao, Guoping, Qin, Zifei, Wu, Baojian, Gonzalez, Frank J., Yao, Xinsheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300989/
https://ncbi.nlm.nih.gov/pubmed/28443723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2017.1323139
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