Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

Icaritin is a natural flavonoid with anti-osteoporosis activity. This study aimed to characterize icaritin glucuronidation by pooled human liver microsomes (HLM) and pooled human intestine microsomes (HIM), and to determine the contribution of individual UDP-glucuronosyltrans-ferase (UGT) enzyme to...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Xenobiotica
Egile Nagusiak: Wang, Li, Hong, Xiaodan, Yao, Zhihong, Dai, Yi, Zhao, Guoping, Qin, Zifei, Wu, Baojian, Gonzalez, Frank J., Yao, Xinsheng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300989/
https://ncbi.nlm.nih.gov/pubmed/28443723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2017.1323139
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