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Effect of the β-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases (UGTs)

Glucuronidation studies using microsomes and recombinant UDP-glucuronosyltransferases (rUGTs) can be complicated by the presence of endogenous β-glucuronidases leading to underestimation of glucuronide formation rates. Saccharolactone is the most frequently used β-glucuronidase inhibitor, although a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Oleson, Lauren, Court, Michael H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697495/
https://ncbi.nlm.nih.gov/pubmed/18718121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1211/jpp.60.9.0009
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