S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen

AIMS: To characterize the kinetics of S-naproxen (‘naproxen’) acyl glucuronidation and desmethylnaproxen acyl and phenolic glucuronidation by human liver microsomes and identify the human UGT isoform(s) catalysing these reactions. METHODS: Naproxen and desmethylnaproxen glucuronidation were investig...

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Autores principales: Bowalgaha, Kushari, Elliot, David J, Mackenzie, Peter I, Knights, Kathleen M, Swedmark, Stellan, Miners, John O
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2005
Materias:
Drug Disposition
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884820/
https://ncbi.nlm.nih.gov/pubmed/16187975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02446.x
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