Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Sequence variability in surface-antigenic sites of pathogenic proteins is an important obstacle in vaccine development. Over 200 distinct genomic sequences have been identified for human papillomavirus (HPV), of which more than 18 are associated with cervical cancer. Here, based on the high structur...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nat Commun
Κύριοι συγγραφείς: Li, Zhihai, Song, Shuo, He, Maozhou, Wang, Daning, Shi, Jingjie, Liu, Xinlin, Li, Yunbing, Chi, Xin, Wei, Shuangping, Yang, Yurou, Wang, Zhiping, Li, Jinjin, Qian, Huilian, Yu, Hai, Zheng, Qingbing, Yan, Xiaodong, Zhao, Qinjian, Zhang, Jun, Gu, Ying, Li, Shaowei, Xia, Ningshao
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group UK 2018
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299097/
https://ncbi.nlm.nih.gov/pubmed/30560935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07199-6
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