Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Sequence variability in surface-antigenic sites of pathogenic proteins is an important obstacle in vaccine development. Over 200 distinct genomic sequences have been identified for human papillomavirus (HPV), of which more than 18 are associated with cervical cancer. Here, based on the high structur...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Li, Zhihai, Song, Shuo, He, Maozhou, Wang, Daning, Shi, Jingjie, Liu, Xinlin, Li, Yunbing, Chi, Xin, Wei, Shuangping, Yang, Yurou, Wang, Zhiping, Li, Jinjin, Qian, Huilian, Yu, Hai, Zheng, Qingbing, Yan, Xiaodong, Zhao, Qinjian, Zhang, Jun, Gu, Ying, Li, Shaowei, Xia, Ningshao
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299097/
https://ncbi.nlm.nih.gov/pubmed/30560935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07199-6
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