Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Sequence variability in surface-antigenic sites of pathogenic proteins is an important obstacle in vaccine development. Over 200 distinct genomic sequences have been identified for human papillomavirus (HPV), of which more than 18 are associated with cervical cancer. Here, based on the high structur...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Li, Zhihai, Song, Shuo, He, Maozhou, Wang, Daning, Shi, Jingjie, Liu, Xinlin, Li, Yunbing, Chi, Xin, Wei, Shuangping, Yang, Yurou, Wang, Zhiping, Li, Jinjin, Qian, Huilian, Yu, Hai, Zheng, Qingbing, Yan, Xiaodong, Zhao, Qinjian, Zhang, Jun, Gu, Ying, Li, Shaowei, Xia, Ningshao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299097/
https://ncbi.nlm.nih.gov/pubmed/30560935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07199-6
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