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Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors

Rivastigmine (Riv) is a potent and selective cholinesterase (acetylcholinesterase, AChE and butyrylcholinesterase, BuChE) inhibitor developed for the treatment of Alzheimer’s disease (AD). To elucidate whether Riv causes neuronal differentiation, we examined its effect on nerve growth factor (NGF)-i...

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Foilsithe in:PLoS One
Main Authors: Terada, Kazuki, Migita, Keisuke, Matsushima, Yukari, Sugimoto, Yumi, Kamei, Chiaki, Matsumoto, Taichi, Mori, Masayoshi, Matsunaga, Kazuhisa, Takata, Jiro, Karube, Yoshiharu
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296549/
https://ncbi.nlm.nih.gov/pubmed/30557385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209250
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