Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors

Rivastigmine (Riv) is a potent and selective cholinesterase (acetylcholinesterase, AChE and butyrylcholinesterase, BuChE) inhibitor developed for the treatment of Alzheimer’s disease (AD). To elucidate whether Riv causes neuronal differentiation, we examined its effect on nerve growth factor (NGF)-i...

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Veröffentlicht in:PLoS One
Hauptverfasser: Terada, Kazuki, Migita, Keisuke, Matsushima, Yukari, Sugimoto, Yumi, Kamei, Chiaki, Matsumoto, Taichi, Mori, Masayoshi, Matsunaga, Kazuhisa, Takata, Jiro, Karube, Yoshiharu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296549/
https://ncbi.nlm.nih.gov/pubmed/30557385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209250
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