Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome

Lynch syndrome (LS) is the most common form of hereditary colon cancer. Germline mutations in the mismatch-repair (MMR) genes MLH1, MSH2 (EPCAM), MSH6, and PMS2, followed by a second hit to the remaining allele, lead to cancer development. Universal tumor screening for LS is routinely performed on c...

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Publicado en:Hum Pathol
Autores principales: Hemminger, Jessica A., Pearlman, Rachel, Haraldsdottir, Sigurdis, Knight, Deborah, Jonasson, Jon Gunnlaugur, Pritchard, Colin C., Hampel, Heather, Frankel, Wendy L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296362/
https://ncbi.nlm.nih.gov/pubmed/29723603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humpath.2018.04.017
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