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Can dimedone be used to study selenoproteins? An investigation into the reactivity of dimedone toward oxidized forms of selenocysteine

Dimedone is a widely used reagent to assess the redox state of cysteine‐containing proteins as it will alkylate sulfenic acid residues, but not sulfinic acid residues. While it has been reported that dimedone can label selenenic acid residues in selenoproteins, we investigated the stability, and rev...

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Publicat a:Protein Sci
Autors principals: Payne, N. Connor, Barber, Drew R., Ruggles, Erik L., Hondal, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295895/
https://ncbi.nlm.nih.gov/pubmed/29451338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3390
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