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Can dimedone be used to study selenoproteins? An investigation into the reactivity of dimedone toward oxidized forms of selenocysteine

Dimedone is a widely used reagent to assess the redox state of cysteine‐containing proteins as it will alkylate sulfenic acid residues, but not sulfinic acid residues. While it has been reported that dimedone can label selenenic acid residues in selenoproteins, we investigated the stability, and rev...

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Bibliografske podrobnosti
izdano v:Protein Sci
Main Authors: Payne, N. Connor, Barber, Drew R., Ruggles, Erik L., Hondal, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295895/
https://ncbi.nlm.nih.gov/pubmed/29451338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3390
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