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No Selenium Required: Reactions Catalyzed By Mammalian Thioredoxin Reductase That Are Independent of a Selenocysteine Residue.

Mammalian thioredoxin reductase (TR) contains a rare selenocysteine (Sec) residue in a conserved redox active tetrapeptide of sequence Gly-Cys(1)-Sec(2)-Gly. The high chemical reactivity of the Sec residue is thought to confer broad substrate specificity to the enzyme. In addition to utilizing thior...

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Detalhes bibliográficos
Main Authors: Lothrop, Adam P., Ruggles, Erik L., Hondal, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754045/
https://ncbi.nlm.nih.gov/pubmed/19366212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802146w
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