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The contribution of selenocysteine to the peroxidase activity of selenoprotein S
Selenoprotein S (SelS, VIMP) is an intrinsically disordered enzyme that utilizes selenocysteine to catalyze the reduction of disulfide bonds and peroxides. Here it is demonstrated that selenocysteine is the residue oxidized by the peroxide substrate. It is possible to trap the reaction intermediate...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3809988/ https://ncbi.nlm.nih.gov/pubmed/23914919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400741c |
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