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The on-fibrillation-pathway membrane content leakage and off-fibrillation-pathway lipid mixing induced by 40-residue β-amyloid peptides in biologically relevant model liposomes

Disruption of the synaptic plasma membrane (SPM) induced by the aggregation of β-amyloid (Aβ) peptides has been considered as a potential mechanism for the neurotoxicity of Aβ in Alzheimer’s disease (AD). However, the molecular basis of such membrane disruption process remains unclear, mainly becaus...

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書誌詳細
出版年:Biochim Biophys Acta Biomembr
主要な著者: Cheng, Qinghui, Hu, Zhi-Wen, Doherty, Katelynne E., Tobin-Miyaji, Yuto J., Qiang, Wei
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295276/
https://ncbi.nlm.nih.gov/pubmed/29548698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2018.03.008
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