Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice

To investigate the role of increased levels of thioredoxin (Trx) in both the cytosol (Trx1) and mitochondria (Trx2) on aging, we have conducted a study to examine survival and age-related diseases using male mice overexpressing Trx1 and Trx2 (TXNTg × TXN2Tg). Our study demonstrated that the upregula...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:GeroScience
Päätekijät: Cunningham, Geneva M., Flores, Lisa C., Roman, Madeline G., Cheng, Christie, Dube, Sara, Allen, Colton, Valentine, Joseph M., Hubbard, Gene B., Bai, Yidong, Saunders, Thomas L., Ikeno, Yuji
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer International Publishing 2018
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294725/
https://ncbi.nlm.nih.gov/pubmed/30121784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-018-0039-6
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