Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice

We examined the effects of continuous overexpression of thioredoxin (Trx) 1 on aging in Trx1 transgenic mice [Tg(TXN)(+/0)]. This study was conducted to test whether increased thioredoxin expression over the lifespan in mice would alter aging and age-related pathology because our previous study demo...

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Detalhes bibliográficos
Publicado no:Pathobiol Aging Age Relat Dis
Main Authors: Flores, Lisa C., Roman, Madeline G., Cunningham, Geneva M., Cheng, Christie, Dube, Sara, Allen, Colton, Van Remmen, Holly, Hubbard, Gene B., Saunders, Thomas L., Ikeno, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201794/
https://ncbi.nlm.nih.gov/pubmed/30370017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20010001.2018.1533754
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