Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice

We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1)(+/0)]. The Tg(TRX1)(+/0) mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type litte...

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Detalhes bibliográficos
Main Authors: Pérez, Viviana I., Cortez, Lisa A., Lew, Christie M., Rodriguez, Marisela, Webb, Celeste R., Van Remmen, Holly, Chaudhuri, Asish, Qi, Wenbo, Lee, Shuko, Bokov, Alex, Fok, Wilson, Jones, Dean, Richardson, Arlan, Yodoi, Junji, Zhang, Yiqiang, Tominaga, Kaoru, Hubbard, Gene B., Ikeno, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Journal of Gerontology: MEDICAL SCIENCES
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210956/
https://ncbi.nlm.nih.gov/pubmed/21873593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glr125
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