Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

Genetic manipulations of Mn superoxide dismutase (MnSOD), SOD2 expression have demonstrated that altering the level of MnSOD activity is critical for cellular function and life span in invertebrates. In mammals, Sod2 homozygous knockout mice die shortly after birth, and alterations of MnSOD levels a...

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Autori principali: Jang, Youngmok C., Pérez, Viviana I., Song, Wook, Lustgarten, Michael S., Salmon, Adam B., Mele, James, Qi, Wenbo, Liu, Yuhong, Liang, Hanyu, Chaudhuri, Asish, Ikeno, Yuji, Epstein, Charles J., Van Remmen, Holly, Richardson, Arlan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2009
Soggetti:
Journal of Gerontology: Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759571/
https://ncbi.nlm.nih.gov/pubmed/19633237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glp100
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