Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

Genetic manipulations of Mn superoxide dismutase (MnSOD), SOD2 expression have demonstrated that altering the level of MnSOD activity is critical for cellular function and life span in invertebrates. In mammals, Sod2 homozygous knockout mice die shortly after birth, and alterations of MnSOD levels a...

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Hlavní autoři: Jang, Youngmok C., Pérez, Viviana I., Song, Wook, Lustgarten, Michael S., Salmon, Adam B., Mele, James, Qi, Wenbo, Liu, Yuhong, Liang, Hanyu, Chaudhuri, Asish, Ikeno, Yuji, Epstein, Charles J., Van Remmen, Holly, Richardson, Arlan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Journal of Gerontology: Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759571/
https://ncbi.nlm.nih.gov/pubmed/19633237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glp100
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