Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

Genetic manipulations of Mn superoxide dismutase (MnSOD), SOD2 expression have demonstrated that altering the level of MnSOD activity is critical for cellular function and life span in invertebrates. In mammals, Sod2 homozygous knockout mice die shortly after birth, and alterations of MnSOD levels a...

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Bibliografiske detaljer
Main Authors: Jang, Youngmok C., Pérez, Viviana I., Song, Wook, Lustgarten, Michael S., Salmon, Adam B., Mele, James, Qi, Wenbo, Liu, Yuhong, Liang, Hanyu, Chaudhuri, Asish, Ikeno, Yuji, Epstein, Charles J., Van Remmen, Holly, Richardson, Arlan
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Journal of Gerontology: Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759571/
https://ncbi.nlm.nih.gov/pubmed/19633237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glp100
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