Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

To test the impact of increased mitochondrial oxidative stress as a mechanism underlying aging and age-related pathologies, we generated mice with a combined deficiency in two mitochondrial-localized antioxidant enzymes, Mn superoxide dismutase (MnSOD) and glutathione peroxidase-1 (Gpx-1). We compar...

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Detalhes bibliográficos
Main Authors: Zhang, Yiqiang, Ikeno, Yuji, Qi, Wenbo, Chaudhuri, Asish, Li, Yan, Bokov, Alex, Thorpe, Suzanne R., Baynes, John W., Epstein, Charles, Richardson, Arlan, Van Remmen, Holly
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Journal of Gerontology: Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781787/
https://ncbi.nlm.nih.gov/pubmed/19776219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glp132
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