Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

Oxidative stress has been implicated in the etiology of age-related muscle loss (sarcopenia). However, the underlying mechanisms by which oxidative stress contributes to sarcopenia have not been thoroughly investigated. To directly examine the role of chronic oxidative stress in vivo, we used a mous...

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Detalhes bibliográficos
Main Authors: Jang, Youngmok C., Lustgarten, Michael S., Liu, Yuhong, Muller, Florian L., Bhattacharya, Arunabh, Liang, Hanyu, Salmon, Adam B., Brooks, Susan V., Larkin, Lisa, Hayworth, Christopher R., Richardson, Arlan, Van Remmen, Holly
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987499/
https://ncbi.nlm.nih.gov/pubmed/20040516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-146308
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