Deletion of Nrf2 Shortens Lifespan in C57BL6/J Male Mice but does not Alter the Health and Survival Benefits of Caloric Restriction

Caloric restriction (CR) is the leading non-pharmaceutical dietary intervention to improve health- and lifespan in most model organisms. A wide array of cellular pathways is induced in response to CR and CR-mimetics, including the transcriptional activator Nuclear factor erythroid-2-related factor 2...

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Udgivet i:Free Radic Biol Med
Main Authors: Pomatto, Laura C.D., Dill, Theresa, Carboneau, Bethany, Levan, Sophia, Kato, Jonathan, Mercken, Evi M., Pearson, Kevin J., Bernier, Michel, de Cabo, Rafael
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382945/
https://ncbi.nlm.nih.gov/pubmed/31953150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.01.005
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