Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8

Dendritic cells (DCs) constantly sample peripheral tissues for antigens, which are subsequently ingested to derive peptides for presentation to T cells in lymph nodes. To do so, DCs have to traverse many different tissues with varying oxygen tensions. Additionally, DCs are often exposed to low oxyge...

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Bibliographic Details
Published in:Biosci Rep
Main Authors: Paardekooper, Laurent M., Bendix, Maura B., Ottria, Andrea, de Haer, Lieke W., ter Beest, Martin, Radstake, Timothy R.D.J., Marut, Wioleta, van den Bogaart, Geert
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294625/
https://ncbi.nlm.nih.gov/pubmed/30463908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20182019
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