Flexibility and structure of flanking DNA impact transcription factor affinity for its core motif

Spatial and temporal expression of genes is essential for maintaining phenotype integrity. Transcription factors (TFs) modulate expression patterns by binding to specific DNA sequences in the genome. Along with the core binding motif, the flanking sequence context can play a role in DNA–TF recogniti...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Yella, Venkata Rajesh, Bhimsaria, Devesh, Ghoshdastidar, Debostuti, Rodríguez-Martínez, José A, Ansari, Aseem Z, Bansal, Manju
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2018
Konular:
Genomics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294565/
https://ncbi.nlm.nih.gov/pubmed/30395339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1057
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