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Mapping Polyamide–DNA Interactions in Human Cells Reveals a New Design Strategy for Effective Targeting of Genomic Sites
Targeting the genome with sequence-specific synthetic molecules is a major goal at the interface of chemistry, biology, and personalized medicine. Pyrrole/imidazole based polyamides can be rationally designed to target specific DNA sequences with exquisite precision in vitro; yet, the biological out...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160732/ https://ncbi.nlm.nih.gov/pubmed/25066383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201405497 |
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