Synthetic genome readers target clustered binding sites across diverse chromatin states

Targeting the genome with sequence-specific DNA-binding molecules is a major goal at the interface of chemistry, biology, and precision medicine. Polyamides, composed of N-methylpyrrole and N-methylimidazole monomers, are a class of synthetic molecules that can be rationally designed to “read” speci...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Erwin, Graham S., Grieshop, Matthew P., Bhimsaria, Devesh, Do, Truman J., Rodríguez-Martínez, José A., Mehta, Charu, Khanna, Kanika, Swanson, Scott A., Stewart, Ron, Thomson, James A., Ramanathan, Parameswaran, Ansari, Aseem Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127382/
https://ncbi.nlm.nih.gov/pubmed/27830652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604847113
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