Synthetic transcription elongation factors license transcription across repressive chromatin

Releasing a paused RNA polymerase II into productive elongation is tightly-regulated, especially at genes that impact human development and disease. To exert control over this rate-limiting step, we designed sequence-specific synthetic transcription elongation factors (Syn-TEFs). These molecules are...

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I publikationen:Science
Huvudupphovsmän: Erwin, Graham S., Grieshop, Matthew P., Ali, Asfa, Jun, Qj, Lawlor, Matthew, Kumar, Deepak, Ahmad, Istaq, McNally, Anna, Teider, Natalia, Worringer, Katie, Sivasankaran, Rajeev, Syed, Deeba N., Eguchi, Asuka, Ashraf, Md., Jeffery, Justin, Mousheng, Xu, Park, Paul M. C., Mukhtar, Hasan, Srivastava, Achal K., Faruq, Mohammed, Bradner, James E., Ansari, Aseem Z.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037176/
https://ncbi.nlm.nih.gov/pubmed/29192133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan6414
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