Synthetic transcription elongation factors license transcription across repressive chromatin

Releasing a paused RNA polymerase II into productive elongation is tightly-regulated, especially at genes that impact human development and disease. To exert control over this rate-limiting step, we designed sequence-specific synthetic transcription elongation factors (Syn-TEFs). These molecules are...

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Publicado no:Science
Main Authors: Erwin, Graham S., Grieshop, Matthew P., Ali, Asfa, Jun, Qj, Lawlor, Matthew, Kumar, Deepak, Ahmad, Istaq, McNally, Anna, Teider, Natalia, Worringer, Katie, Sivasankaran, Rajeev, Syed, Deeba N., Eguchi, Asuka, Ashraf, Md., Jeffery, Justin, Mousheng, Xu, Park, Paul M. C., Mukhtar, Hasan, Srivastava, Achal K., Faruq, Mohammed, Bradner, James E., Ansari, Aseem Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037176/
https://ncbi.nlm.nih.gov/pubmed/29192133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan6414
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