Specificity landscapes unmask submaximal binding site preferences of transcription factors

We have developed Differential Specificity and Energy Landscape (DiSEL) analysis to comprehensively compare DNA–protein interactomes (DPIs) obtained by high-throughput experimental platforms and cutting edge computational methods. While high-affinity DNA binding sites are identified by most methods,...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Bhimsaria, Devesh, Rodríguez-Martínez, José A., Pan, Junkun, Roston, Daniel, Korkmaz, Elif Nihal, Cui, Qiang, Ramanathan, Parameswaran, Ansari, Aseem Z.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233140/
https://ncbi.nlm.nih.gov/pubmed/30341220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811431115
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