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Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases
LAGLIDADG homing endonucleases (meganucleases) are site-specific mobile endonucleases that can be adapted for genome-editing applications. However, one problem when reprogramming meganucleases on non-native substrates is indirect readout of DNA shape and flexibility at the central 4 bases where clea...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6294521/ https://ncbi.nlm.nih.gov/pubmed/30357419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky976 |
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