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A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI
Insight into protein structure and function is best obtained through a synthesis of experimental, structural and bioinformatic data. Here, we outline a framework that we call MUSE (mutual information, unigenic evolution and structure-guided elucidation), which facilitated the identification of previ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853131/ https://ncbi.nlm.nih.gov/pubmed/20061372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1223 |
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