लोड हो रहा है...
Modifying a covarying protein–DNA interaction changes substrate preference of a site-specific endonuclease
Identifying and validating intermolecular covariation between proteins and their DNA-binding sites can provide insights into mechanisms that regulate selectivity and starting points for engineering new specificity. LAGLIDADG homing endonucleases (meganucleases) can be engineered to bind non-native t...
में बचाया:
| में प्रकाशित: | Nucleic Acids Res |
|---|---|
| मुख्य लेखकों: | , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
2019
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6847045/ https://ncbi.nlm.nih.gov/pubmed/31602462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz866 |
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