CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

The membrane attack complex (MAC) is one of the immune system’s first responders. Complement proteins assemble on target membranes to form pores that lyse pathogens and impact tissue homeostasis of self-cells. How MAC disrupts the membrane barrier remains unclear. Here we use electron cryo-microscop...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Menny, Anaïs, Serna, Marina, Boyd, Courtney M., Gardner, Scott, Joseph, Agnel Praveen, Morgan, B. Paul, Topf, Maya, Brooks, Nicholas J., Bubeck, Doryen
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294249/
https://ncbi.nlm.nih.gov/pubmed/30552328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07653-5
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