CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

The membrane attack complex (MAC) is one of the immune system’s first responders. Complement proteins assemble on target membranes to form pores that lyse pathogens and impact tissue homeostasis of self-cells. How MAC disrupts the membrane barrier remains unclear. Here we use electron cryo-microscop...

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Publicado no:Nat Commun
Main Authors: Menny, Anaïs, Serna, Marina, Boyd, Courtney M., Gardner, Scott, Joseph, Agnel Praveen, Morgan, B. Paul, Topf, Maya, Brooks, Nicholas J., Bubeck, Doryen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294249/
https://ncbi.nlm.nih.gov/pubmed/30552328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07653-5
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