Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells

BACKGROUND: Celastrol is a major active component of the thunder god vine (Tripterygium wilfordii) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K–Akt–mTOR signaling, which is frequently dysregulated in tumors and critical for tumor...

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Bibliografske podrobnosti
izdano v:Onco Targets Ther
Main Authors: Li, Xiaoli, Zhu, Guangbei, Yao, Xintong, Wang, Ning, Hu, Ronghui, Kong, Qingxin, Zhou, Duanfang, Long, Liangyuan, Cai, Jiali, Zhou, Weiying
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2018
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294079/
https://ncbi.nlm.nih.gov/pubmed/30588010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S187315
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