Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells

BACKGROUND: Celastrol is a major active component of the thunder god vine (Tripterygium wilfordii) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K–Akt–mTOR signaling, which is frequently dysregulated in tumors and critical for tumor...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Li, Xiaoli, Zhu, Guangbei, Yao, Xintong, Wang, Ning, Hu, Ronghui, Kong, Qingxin, Zhou, Duanfang, Long, Liangyuan, Cai, Jiali, Zhou, Weiying
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294079/
https://ncbi.nlm.nih.gov/pubmed/30588010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S187315
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