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Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells
BACKGROUND: Celastrol is a major active component of the thunder god vine (Tripterygium wilfordii) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K–Akt–mTOR signaling, which is frequently dysregulated in tumors and critical for tumor...
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| Pubblicato in: | Onco Targets Ther |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Dove Medical Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6294079/ https://ncbi.nlm.nih.gov/pubmed/30588010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S187315 |
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