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Effects of the FcRn developmental pharmacology on the pharmacokinetics of therapeutic monoclonal IgG antibody in pediatric subjects using minimal physiologically-based pharmacokinetic modelling

The aim of this study was to investigate neonatal Fc receptor (FcRn) concentration developmental pharmacology in adult and pediatric subjects using minimal physiologically-based pharmacokinetic (mPBPK) modelling. Three types of pharmacokinetic (PK) data for three agents (endogenous/exogenous native...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:MAbs
Hauptverfasser: Hardiansyah, Deni, Ng, Chee Meng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291265/
https://ncbi.nlm.nih.gov/pubmed/29969360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1494479
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